Pharmacology MCQ Answer 497
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Physostigmine has a tertiary nitrogen in its structure and is uncharged at physiological pH (thus it can get into the CNS), unlike neostigmine, which is a quaternary N-containing compound. Physostigmine can be used to treat poisoning by muscarinic antagonists like atropine that are distributed to the CNS. Since atropine acts as a competitive pharmacological antagonist, its effect can be antagonized by ACh which competes with it for muscarinic receptors.
Cyclobenzaprine (Flexaril)
Used for muscle spasms. Advantage over Valium - does not produce as much dependence.
Mechanism of action is unknown, but it does block the reuptake of NE; therefore, do not use this drug with a MAO inhibitor because the MAO inhibitor will build up the amount of NE prejunctionally., Cyclobenzaprine will further increase the amount of NE in the junction. This may cause real tachycardia. Side effects are quite similar to those of Scopolamine, an anticholinergic drug. These include sedation, drowsiness, dry mouth, tachycardia, blurred vision, and colorful dreams if you're lucky.
Category: Pharmacology MCQs
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