Digestion of Fat

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USMLE Step 2 SecretsAnswer: ADE

DISCUSSION: Micellar solution provides an optimal environment for the action of pancreatic lipase. Pro-co-lipase is converted to co-lipase by trypsin. Co-lipase binds to triglyceride, then lipase complexes with co-lipase, and triglyceride hydrolysis access. Pancreatic lipase hydrolyzes triglyceride into 2-monoglyceride and fatty acids. The 2-monoglyceride and fatty acid enter the micellae. An alkaline pH allows lipase to function optimally. Micellar fatty acids and 2-monoglyceride pass into the epithelial cell by diffusion.

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