Physiology MCQ Answer 07
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DISCUSSION:
- Intramolecular and intermolecular cross-links are crucial for collagen structural stability.
- Formation of cross-links can be inhibited by two pharmacologic agents: beta-aminopropionitrile inhibits the enzyme lysyl oxidase, and D-penicillamine binds to collagen substrate directly to prevent collagen cross-link formation.
- Iron is a cofactor for prolyl hydroxylase, which is important for collagen synthesis.
- In high enough concentration, proline analogs prevent collagen formation with minimal effects on noncollagenase protein synthesis.
Category: Physiology MCQs
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