Answer to Pharmacology MCQ 459

The Correct Option is A

The total distribution clearance of propofol and thiopental ranges from 3 to 4 liters.minute^-1.70 kg^-1, a value that is approximately 60 to 80% of the cardiac output. This suggests that propofol and thiopental distribution to body tissues will be governed by cardiac output and regional blood flow. The large steady state volumes of distribution for propofol and thiopental suggest extensive partitioning into muscle and fat tissue. The long (and clinical irrelevant) elimination half-lives of propofol and thiopental result from the slow elimination of drug from the large stores in fat and muscle.

Thiopental redistribution phenomenon with first peak in blood, then in brain, muscle, then fat, then slowly released, the more fat you have later you wake up from thiopental (phenobarbital has longer duration of action).

Category: Pharmacology MCQs