Answer to Pharmacology MCQ 453
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Inositol Triphosphate and Diacylglycerol
- Inositol-1,4,5-triphosphate (IP3)
- Second messenger generated from a relatively rare membrane phospholipid (PIP2)
- Occurs upon activation of enzyme phospholipase C
- Cleaves PIP2 into two different molecules = IP3 and diacylglycerol (DAG) (also a 2nd messenger)
- Sequence begins with binding of G protein to activate phospholipase C
- IP3 is water soluble and diffuses through cytosol to bind to IP3 receptor channel in the ER, causing it to open and release calcium into the cytosol
- DAG remains in the membrane where it activates protein kinase C (PKC) family of enzymes
- Phosphorylates a variety of proteins (serine and threonine groups)
Category: Pharmacology MCQs
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