MCQ Hematology Answer 1

The correct answer is B
Explanation

Hemochromatosis is a condition caused by excessive iron accumulation in the body most of which is deposited in the parenchymal cells of various organs particularly liver and pancreas. The excess iron deposition in the parenchymal cells of various organs leads to dysfunction and ultimate failure of these organs. The organs most commonly affected are the liver and the pancreas. Liver undergoes micro-nodular cirrhosis due deposition of iron in the periportal hepatocytes and in pericanalicular lysosomes. Bile duct epithelium and kupffer cell pigmentation is less marked. Pancreas becomes intensely pigmented, has interstitial fibrosis and parenchymal atrophy. Iron deposits are found in both acinar and islet cells.

This responsible for pancreatic failure and development of diabetes mellitus. The intensity of iron staining in the pancreatic islets correlates with occurrence and severity of diabetes. Bronze pigmentation of skin is due to the deposition of iron in the dermal macrophages and fibroblasts.

So as per the above explanation a person suffering from hemochromatosis will present with a triad of micro-nodular liver cirrhosis, diabetes mellitus and bronze pigmentation of the skin. therefore the correct answer is B A,C,& D are not the correct answers because anemia-- sickle cell or iron deficiency is not a manifestation of hemochromatosis E is also incorrect because Kayser-Fleischer ring is seen in Wilson's disease and not in hemochromatosis.

Category: Hematology MCQs