The correct answer is AHyperparathyroidism is the most common cause of hypercalcemia in the outpatient population.
85% is secondary to a solitary parathyroid adenoma. 15% results from hyperplasia or multiple adenomas. <1% is due to parathyroid carcinoma.
Three forms of Hyperparathyroidism exist.
- Primary hyperparathyroidism, the most common form, results from either a parathyroid adenoma(s), or hyperplasia. 75% of primary hyperparathyroidism patients are female, usually postmenopausal.
- Secondary hyperparathyroidism entails hyperplasia of the parathyroids secondary to dysfunction of another organ system. Renal failure is the most common culprit, though secondary hyperparathyroidism may also be seen in osteogenesis imperfecta, Paget’s disease, multiple myeloma, carcinoma with bony metastasis, and pituitary basophilism.
- Tertiary hyperparathyroidism typically arises in the setting of chronic renal failure. Serum calcium is typically low or normal with an elevated, irrepressible PTH. The only viable treatment option is surgery.
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Karnataka PGET 2007 MCQs
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