CARD 15 Mutation
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Answer B. There is no association between CARD 15 mutations and UC. CARD 15 mutations are found in up to 35% of patients with Crohns disease. They are more common in familial than sporadic disease and are not found or rare in Japan. CARD 15 mutations are associated with ileal and fibrostenosing disease. The presence of CARD 15 mutations in mny unaffected persons indicates that additional genes or environental factors are also necessary for phenotypic expression of Crohns disease.
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