H. pylori infection

Answer B

H. pylori infection may protect against the development of reflux disease because pangastritis leads to a reduction is acid secretory capability. Treatment may lead to recovery of acid secretion and the potential for worsening reflux although eradication studies have not been performed in this population specifically. Therapy for H. pylori is unlikely to alter the natural history of gastric adenocarcinoma and its relationship to cardiac cancer (as opposed to distal antral cancer) is less established. The autoimmune polyglandular Syndrome is associated with atrophic gastritis and pernicious anemia as a consequence of autoimmune destruction of parietal cells (often with positive autoimmune markers) and not from chronic H. pylori infection. Undifferentiated dyspepsia in young patients without trigger factors is appropriately treated with antibiotics in order to cure those with peptic ulcers (1 in 7) and reduce the burden of endoscopy.

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