Option D
Exposure to a substance does not necessarily mean absorption. In order for a substance to be absorbed it must first make physical contact and cross the membrane barrier. Depending on the hydro (water) or lipo (lipid) properties of the substance, toxic agents can penetrate these barriers and produce unwanted effects.
Substances can cross these barriers by several methods: diffusion across a concentration gradient; facilitated diffusion through the use of carrier proteins; active transport; and phagoytosis.
The action of these substances can also be dependent on the route of absorption or penetration.
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