MCQ Hematology Answer 16

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Answer: B


An alpha2 antiplasmin deficiency will cause bleeding, particularly after an invasive procedure when the fibrinolytic system is activated, and (as seen in this case) it will not cause abnormalities in the screening coagulation studies. The normal screening coagulation studies in the patient make it very unlikely that coagulation screening of the mother, a factor XI level, or a d-Dimer will be helpful in this evaluation. Electron microscopic study of the patient’s platelets is not indicated in the face of the normal platelet studies that have been reported.


References:

  1. Saito H. 2-plasmin inhibitor and its deficiency states. J Lab Clin Med 1988; 112:671-78.

  2. Miles LA, Plow EF, Donnelly KJ, Hougie C, Griffin JH. A bleeding disorder due to deficiency of alpha 2-antiplasmin. Blood 1982; 59:1246-51.

Category: Hematology MCQs

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