MCQ Pharmacology Answer 3
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Explanation
Phenytoin is approximately 90 per cent bound to serum albumin. Therefore, in an initial total plasma phenytoin concentration of 20ìg/ml represents the sum of the protein bound drug (90 per cent of 20 = 18ìg/ml) and the unbound drug (10 per cent of 20 = 2ìg/ml). The unbound drug is available for distribution to the site of therapeutic effect (ie, the brain), peripheral tissues, and the site of elimination (the liver). The bound drug is confined to the bloodstream.
Tags: MCQS, Pharmacology, Pharmacokinetics
Category: Pharmacology MCQs
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