MCQ Answer 1
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Explanation
- Low-dose aspirin (up to 1-2 g/day) decreases renal urate excretion, especially in the setting of low albumin.
- Paradoxically, high-dose aspirin actually has a uricosuric effect, leading to an increase in urate excretion.
- Estrogen also exerts a uricosuric effect.
- It is possible that declining use of postmenopausal estrogen replacement may lead to an increase in postmenopausal gout and an earlier age of onset.
- Cardiovascular drugs, losartan and fenofibrate, also have uricosuric effects.
Tags: MCQS, Pharmacology, Drug Interactions
Category: Pharmacology MCQs
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