Irritable bowel syndrome

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Harrison's Principles of Internal Medicine, Self-Assessment and Board ReviewThe Correct Answer is D

Irritable bowel syndrome has been treated by increasing dietary fibre, however some patients find that excess bran makes the symptoms worse. In one study, 70% of patients improved on a bland diet free of wheat and milk. Increased fermentation in the gut is directly implicated as a trigger for the condition. Metronidazole substantially alters the aerobic/anaerobic balance within the bowel and can increase the fermentation rate. Nystatin has been shown to decrease fermentation and improves symptoms. Stress is a well known trigger factor and hypnosis and relaxation techniques decrease the symptoms and the relapse rate if IBS.

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