MCQ Pharmacology Answer 19
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Explanation
Class Ic antiarrhythmic agents markedly depress the phase 0 depolarization (decreasing Vmax). They decrease conductivity, but have a minimal effect on the action potential duration. Of the sodium channel blocking antiarrhythmic agents (the class I antiarrhythmic agents), the class Ic agents have the most potent sodium channel blocking effects.
Class Ic agents are indicated for life-threatening ventricular tachycardia or ventricular fibrillation, and for the treatment of refractory supraventricular tachycardia (ie: atrial fibrillation).
Class Ic agents include encainide, flecainide, moricizine, and propafenone.
Tags: MCQ, Pharmacology, Anti-Arrythmics
Category: Pharmacology MCQs
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