Physiology MCQ Answer 37
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Parietal cells secrete H+ into the lumen across their apical membranes in exchange for K+ by the (H+,K+) ATPase. The Na+ concentration decreases as flow rate increases, with gastric juice changing from predominantly NaCl to HCl. Cl- enters the parietal cell in exchange for HCO3- and exits into the lumen through channels. K+ concentrations are always higher in gastric juice than in plasma; chronic vomiting can lead to hypokalemia. H+ is pumped against a concentration gradient that can reach >106 to 1. Thus acid secretion requires lots of ATP, which requires lots of mitochondria. Parietal cells are rich in mitochondria.
Category: Physiology MCQs
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