76 MCQs in Pathology Answer

The Correct option is C

It is the interaction of oncoproteins E6 and E7 with various cellular proteins that immortalizes HPV cells in high-risk HPV. Two of HPV’s oncoproteins, E6 and E7, interact with two tumor suppressor cellular proteins, p53 and pRb respectively. When E6 interacts with p53, p53 is degraded resulting in the immortalization of HPV cells because p53 can no longer monitor the cellular repair process.

E7 evolved from the same common ancestor as E6 and interacts with p105Rb which allows the release of E2F transcription factors and activates genes that promote the cell cycle. Additionally, E7 also blocks negative cell cycle regulators like cyclin-dependent kinase inhibitors. Furthermore, E7 is a mitotic mutator, meaning that it induces centrosome abnormalities to generate aneuploidy. Like E6, E7 is present continuously during carcinogenesis.

Category: Pathology MCQs