108 MCQs in Pathology Answer
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The use of thrombolytic drugs also raises the potential for intramyocardial hemorrhage, which would increase the volume and pressure on the poorly healing heart; this overload can cause the heart to rupture. One particular study on the relation between thrombolysis and rupture is the Late Assessment of Thrombolytic Efficacy (LATE) study by Becker and associates. The study demonstrated that the group receiving rt-PA within 6 to 12 hours of symptom onset had the highest number of ruptures, but the data were not statistically significant.
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