COMEDK 2007 MCQ Answer 22
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The correct answer is A
DRUG INDUCED SLE
DRUG INDUCED SLE
- Most common drug is procainamide, which induces ANA in 50-75% of individuals within a few month
- 20% of these patients develop a clinical drug induced lupus, which may consist of polyarthralgias, systemic symptoms, anemia, leukopenia, thrombocytopenia, rheumatoid factors, false positive VDRL and positive coombs test.
- Hydralazine is another common drug that induces ANA in 25-30% of patients and lupus like symptoms in 10% of patients.
- The major serological differences between drug induced lupus and non-drug induced lupus is that antihistone bodies are more common in drug induced lupus while it is very rare to find anti double stranded antibodies on Smith antigen in drug induced lupus.
- Identical to SLE except when take the drug away, patient gets better (duh)
- Linkage with HLA-DR4
Tags: Anti histone antibodies
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