122 MCQs in Pathology Answer
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Small Cell Carcinoma: highly malignant tumor has a distinctive cell type...the epithelial cells are generally small, have little cytoplasm, and are small, round, and oval and, lack nucleoli...
A high mitotic rate is characteristic, with an average of 60 to 70 mitoses per 10 high-power fields. Necrosis is frequent and extensive. Basophilic nuclear staining of vascular walls by DNA from necrotic tumor cells (the Azzopardi effect) is common in necrotic areas. Although there is no absolute measure for the size of the tumor cells, a useful rule of thumb in small cell carcinoma is the diameter of three small lymphocytes.
The important difference between small cell carcinoma and other lung cancers is its more marked sensitivity to chemotherapy.
Category: Pathology MCQs
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