MCQ MAHE 2000 Physiology Answer 11
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There are three distinct atrial natriuretic factor receptors identified so far in mammals, natriuretic peptide receptors A, B and C (NPRA or NPR1, NPRB or NPR2 and NPRAC or NPR3). NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein linked and furthermore is a "clearance receptor" which acts to internalise and destroy the ligand.
ANP activation of the ANP receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG) which will then induce smooth muscle relaxation.
Tags: MCQ, MAHE, Physiology, ANF, ANP, Atrial Natriuretic Factor
Category: MAHE 2000 MCQs
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