MCQ MAHE 2000 Pharmacology Answer 02
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Vigabatrin works by irreversibly inhibiting GABA transaminase thus raising whole brain GABA. Tiagabine works by blocking GABA reuptake once it is released.
The drug, gamma-vinyl GABA (GVG), blocks the release of dopamine in the brain. Dopamine is a neurotransmitter that is believed to be associated with many types of addictive behaviors, according to the report in the August 19, 1999 issue of Synapse (Vol. 84, pp. 11-19). Blocking its release could reduce the addictive tendencies of drugs that boost brain levels of dopamine, such as heroin and alcohol.
GVG, marketed as Vigabatrin, is currently available in Canada and the UK to treat epilepsy but is not yet approved for use in the US.
Tags: MCQ, Pharmacology, Vigabatrin, antiepileptics
Category: MAHE 2000 MCQs
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