Karnatak PGET 2007 Microbiology MCQ Answer 3
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C3 binds covalently within the region extending from the last 20 residues of the variable region through the first 20 residues of CH2.
The CH2 domain is the binding site for Clq with the exposed ß strand of Glu318, Lys320, and Lys322 important .
Amino acid changes within CH2 result in the inability of IgG4 to activate complement and contribute to the differential abilities of the other isotypes to activate complement.
Tags: Immunology, Complement, IgG
Category: Karnataka PGET 2007 MCQs
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