MCQ Hematology Answer 20

The first step in this process is the activation of thrombomodulin by thrombin. Subsequently, protein C combines with thrombomodulin in order to produce activated Protein C .

Activated protein C then combines with protein S on the surface of a platelet (platelets are the clotting cells that circulate in the blood and provide phospholipids to support that clotting process). Activated protein C can then degrade factor Va and factor VIIIa.

Thrombomodulin is an endothelial cell surface bound protein that functions as a cofactor in the thrombin mediated activation of Protein C, a protein circulating in plasma as an inactive zymogen of a serine protease.

The activation of Protein C via the thrombin-thrombomodulin complex takes place close to the intact endothelial cell lining of the blood vessels as soon as the coagulation cascade has been initiated.

Category: Hematology MCQs