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CHuman Parvovirus is the etiologic agent causing erythema infectiosum (Fifth Disease), a common pediatric illness. Maternal infection has been associated with hydrops fetalis and fetal death.
Anemia in newborn infants is a common manifestation of hemolytic disease or congenital parvovirus B19 infection. Parvovirus infection of erythroid precursors in the bone marrow leads to sudden cessation of erythropoiesis. Duration of Parovirus infection is 7 – 10 days, but mature red cells live for about 10 days, so hemoglobin falls suddenly. The RBC’s are normal size, but the erythroid precursor is the “size of a Volkswagen, absolutely enormous,” which is typical of parvovirus infection.
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Pathology MCQs
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